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Home > News > Gut Health Trends >GKM3™ Promotes AKK bacteria & regulates gut metabolic mechanisms
Why still gained weight even when didn’t eat much? If you had the "obesity-prone constitution," it might relate to gut microbiota imbalance. Studies found that the gut microbiota of obese people was different from slim people. Among them, AKK bacteria (Akkermansia muciniphila) was regarded as new-generation "slim bacterium."
A randomized controlled trial published in *Nature Medicine* in May 2026, involving 90 overweight or obese adults, found that supplementation with pasteurized AKK bacteria suppressed weight regain after weight loss. About 40% participants in probiotic group continued losing weight during the maintenance period, compared with only 5% in the placebo group. The study further revealed its mechanism: AKK bacteria could remodel gene expression in adipose tissue, shifting from pro-inflammatory state to rebound to more active metabolic state, while possibly increasing fecal energy excretion.
GKM3™ Lactobacillus plantarum proven by research to promote AKK bacteria growth and enhance metabolism.
GKM3™'s mechanisms including:
- Secrete bile salt hydrolase (BSH): reduce fat absorption, increase fecal fat excretion
- Promote AKK bacteria growth: boost metabolic power, improve obesity-prone constitution
- Regulate gut metabolic mechanisms: inhibit fat synthesis, increase fatty acid oxidation
- Alter gut microbiota: increase beneficial bacteria such as Akkermansia and Collinsella
Animal studies showed GKM3™ lower body fat by 14%, liver lipid, triglyceride, cholesterol and increased total fecal lipid excretion by 2 times. Its human double-blind RCT clinical trial published and confirmed positive benefits for weight management and metabolic regulation.